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Mississippi River Cruise
(Memphis to St. Louis)

8 days with American Cruise Lines  Rating: Deluxe

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  • Enjoy a free open-bar cocktail hour every evening before dinner. Click here for eligible departures.
  • Receive free shore excursions on select river cruises. Click here for eligible departures.

Offers subject to change or withdrawal, availability is limited. Some discounts are not combinable.

River Cruise Itinerary
Day 1 Memphis, TN
Excitement resonates as you reach America’s third-largest inland port, famous for blues, barbeque, and Elvis Presley's Graceland. Less-touted attractions, such as the Pink Palace and Mud Island’s River Walk, replicating 1,000 miles of Mississippi River history and geography along an intriguing six-block stroll, are just as intriguing. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for it all. As you disembark, immerse yourself in the sights and sounds of one of the mid-South's most remarkable cities.
Day 2 Day of River Cruising
Enjoy cruising as Queen of the Mississippi makes its way along the Ohio River. Bird watchers and nature enthusiasts will find the top deck of the Queen of the Mississippi the ideal location to identify different species of birds and other wildlife that call the Ohio River home.
Day 3 Columbus, KY
Relive the Civil War era in this historic town best known for its seizure by Confederate forces in September 1861. A large anchor chain was stretched from one side of the Mississippi River to Belmont, one of several events commemorated at Columbus-Belmont State Park. Learn about the Battle of Belmont at the park’s museum and bring home charming souvenirs from the site’s gift shop.
Day 4 Paducah, KY
Paducah, KY, became a major travel destination in 1991, when the National Quilt Museum opened its doors in the city. Every year, more than 40,000 quilting enthusiasts visit the Museum to see a wide variety of exhibits. For fans of art, Paducah’s LowerTown is home to a successful artist relocation program, where you can participate in creative workshops and discussions with professional artists.”
Day 5 Day of River Cruising
Queen of the Mississippi continues down the river as we make our way to Cape Girardeau, MO. Leisure and relaxation abound on this lovely stretch of the Mississippi River.
Day 6 Cape Girardeau, MO
Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.
Day 7 Chester, IL
Mississippi River cruisesChester is a beautiful region of Illinois located on the bluffs of the Mississippi River. This city has a diverse and storied history, beginning with the establishment of a ferry system by Jane Thomas in the early 1800s. Chester is home to Popeye's creator Elzie C. Segar and you may see the Sailor Man's likeness in the town's own six-foot-tall bronze metal statue 
Day 8 St. Louis, MO
Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest man-made monument in the U.S. Get settled in and acquainted at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country.
Tour Map
All This Included
Journey to the heart and soul of America on American Cruise Lines’ brand new Mississippi Riverboat, Queen of the Mississippi. The Queen of the Mississippi embodies the spirit of traditional Mississippi River paddlewheel cruises and the grandeur of the riverboats of the past, while offering all the modern comforts and amenities American Cruise Lines' passengers have come to expect. As you enjoy the rhythms of the churning river, you’ll explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America. The splendor of the Queen of the Mississippi, coupled with the rich history and heritage of this region, makes this an adventure to remember.
  • Dining service, snacks and complimentary cocktail parties.
  • Oversized staterooms – largest in industry.
  • Most with private balconies.
  • Flat screen satellite TV and DVD players in all staterooms.
  • Wireless internet access shipwide.
  • Hairdryers in all staterooms.
  • Individual climate control in all staterooms.
Accommodations on this Tour
Category A cabin onboard Queen of the Mississippi or America
  • Cabin upgrades are available.
  • Itinerary is subject to change.
  • Fares do not include shore tours, gratuities, or port charges.
  • Please ask your Vacations To Go travel counselor for more information.
Terms and Conditions

* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.

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